Formulation of Metformin Sustained Release Tablet Using Natural Polymer

The overall objective of the present work was to develop an oral sustained-release (SR) Metformin tablet that is prepared by direct compression method using hydrophilic hydroxyl propyl methyl cellulose (HPMC) and Guar gum polymer alone as well in combination at different concentrations. a biguanide has relatively short plasma half-life. It low absolute bioavailability. All properties were evaluated for thickness, weight variation, hardness drug content uniformity vitro release. mean dissolution time used characterize release rate from dosage form indicates release-retarding efficiency polymer. matrix HPMC could not control effectively 12 h but when combined with gum, it slow down and, thus, can be successfully employed formulating Sustain Release tablets.
 Keywords: hydroxylpropylmethylcellulose, tablets, kinetics,